Published by Jan Chaboya-Hembree
Graves’ disease is an autoimmune disorder that leads to over activity of the thyroid gland (hyperthyroidism).
The thyroid gland is an important organ of the endocrine system. It is located in the front of the neck just below the voice box. This gland releases the hormones thyroxine (T4) and triiodothyronine (T3), which control body metabolism. Controlling metabolism is critical for regulating mood, weight, and mental and physical energy levels. If the body makes too much thyroid hormone, the condition is called hyperthyroidism. (An underactive thyroid leads to hypothyroidism.)
The trigger for autoantibody production is unknown.
Since Graves’ disease is an autoimmune disease which appears suddenly, often quite late in life, it is thought that a viral or bacterial infection may trigger antibodies which cross-react with the human TSH receptor (a phenomenon known as antigenic mimicry, also seen in some cases of type I diabetes. One possible culprit is the bacterium Yersinia enterocolitica (not the same as Yersinia pestis, the agent of bubonic plague). Although there is indirect evidence for the structural similarity between the bacterium and the human thyrotropin receptor, direct causative evidence is limited. Yersinia seems not to be a major cause of this disease, although it may contribute to the development of thyroid autoimmunity arising for other reasons in genetically susceptible individuals. It has also been suggested that Y. enterocolitica infection is not the cause of autoimmune thyroid disease, but rather is only an associated condition; with both having a shared inherited susceptibility. More recently, the role for Y. enterocolitica has been disputed.
Some of the eye symptoms of hyperthyroidism are believed to result from heightened sensitivity of receptors to sympathetic nervous system activity, possibly mediated by increased alpha-adrenergic receptors in some tissues.Some people may have a genetic predisposition to develop TSH receptor autoantibodies. HLADR (especially DR3) appears to play a significant role.
• Breast enlargment in men
• Difficulty concentrating
• Eyeballs that stick out (exophthalmos)/ Eye irritation and tearing
• Frequent bowel movements
• Goiter (possible)
• Heat intolerance
• Increased appetite
• Increased sweating
• Menstrual irregularities in women
• Muscle weakness
• Rapid or irregular heartbeat (palpitations or arrhythmia)
• Restlessness and difficulty sleeping
• Shortness of breath with exertion
• Weight loss (rarely, weight gain)
1996 survey study respondents reported a significant decline in memory, attention, planning, and overall productivity from the period 2 years prior to Graves’ symptoms onset to the period when hyperthyroid. In addition, hypersensitivity of the central nervous system to low-grade hyperthyroidism can result in an anxiety disorder before other Graves’ disease symptoms emerge. Panic disorder has been reported to precede Graves’ hyperthyroidism by 4 to 5 years in some cases, although it is not known how frequently this occurs.
The two signs that are truly ‘diagnostic’ of Graves’ disease (i.e., not seen in other hyperthyroid conditions) are exophthalmos (protuberance of one or both eyes) and pretibial myxedema, a rare skin disorder with an occurrence rate of 1-4%, that causes lumpy, reddish skin on the lower legs. Graves’ disease also causes goitre (an enlargement of the thyroid gland) that is of the diffuse type (spread throughout the gland). This phenomenon also occurs with other causes of hyperthyroidism, though Graves’ disease is the most common cause of diffuse goiter. A large goiter will be visible to the naked eye, but a smaller goiter (very mild enlargement of the gland) may be detectable only by physical exam. Occasionally, goiter is not clinically detectable but may be seen only with CT or ultrasound examination of the thyroid.
Graves’ Disease Symptoms
The onset of Graves’ disease symptoms is often insidious: the intensity of symptoms can increase gradually for a long time before the patient is correctly diagnosed with Graves’ disease, which may take months or years.
Traditional treatment: (1) anti-thyroid medication (2) radioactive iodine, which kills the overactive thyroid, cells (3) removal of thyroid gland surgically.
Marijuana is used to treat some of the symptoms of Graves’ disease not the disease itself! The patient needs to see an endocrinologist for a positive diagnosis.
Symptoms that can be treated with medical marijuana are:
• reduce eye pressure
• reduce anxiety
• relieve insomnia
• reduce irritability
• encourage appetite/weight gain
• relieve restlessness / nervousness
• slow or relax heart rate
Recommendations: Sativa strains for daytime and Indica strains for late afternoon and evening. Alternatively, a 50% sativa | 50% indica for all day.
Medical Marijuana and Graves Disease
As with many medical conditions or treatments, the use of conventionally prescribed drugs often comes with potentially serious side effects as well. In the case of Graves Disease, radioiodine therapy may cause an increase in the eye related symptoms of the disease, as well as tenderness in your neck. Anti-thyroid drugs can cause joint pain, liver failure or a decrease in the production of white blood cells that are critical for fighting disease. Beta blockers can cause an asthma attack in asthma patients as well as interfere with the management of diabetes.While medical marijuana has not been shown to directly reduce the production of thyroid hormones, it can certainly be used as a safer alternative to treat many of the symptoms associated with Graves Disease. Medical marijuana, for example, has a long history as a viable treatment for loss of appetite, insomnia and fatigue as well as for pain and anxiety. In addition, medical marijuana does not cause many of the serious side effects associated with traditional Grave Disease treatments.
Marijuana and Graves Disease: Clinical Evidence
For Graves Disease patients who are suffering from loss of appetite or weight loss as a result of the disease, medical marijuana may be an excellent option. Studies have repeatedly shown the effectiveness of medical marijuana as an appetite stimulant. Cancer patients who are undergoing chemotherapy have been studied using medical marijuana with excellent results showing that medical marijuana does work to activate the appetite. Although accepted as a valid anti-stress, anti-anxiety treatment for centuries, medical marijuana has also recently been shown in clinical trials to reduce anxiety levels on patients suffering from anxiety.
Along with acting as an appetitive stimulant and anti-anxiety treatment, medical marijuana can be used to help with any pain related to Graves Disease. Conventional treatments often leads to painful side-effects such as joint pain. Studies have shown that not only does medical marijuana significantly decrease pain levels, but it can also work to reduce a patient’s dependence on opiate based pain medications that are commonly prescribed for pain. By reducing the patient’s dependence on opiate based pain medications, the patient is at less risk for overdose, dependence or addiction.