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Hypertension reduced by Cannabinoids

by 420insight on April 5, 2015
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Cannabinoids reduce hypertension to normal levels:

Cannabis is known to reduce hypertension to normal levels with regular use and to maintain normal levels with continued use in some cases.  Because of repeated threats by the federal government, only a few physicians have elected to recommend medical marijuana in cases of severe high blood pressure.
Recent research indicates that the body's internal cannabinoid system plays an important role in regulating blood pressure, but a full understanding of the exact mechanisms awaits further research.  Animal studies have demonstrated that annadamide and other endocannabinoids suppress hypertension.
Emerging research indicates that the endogenous cannabinoid system plays a role in regulating blood pressure, though its mechanism of action is not well understood.  Animal studies demonstrate that anandamide and other endocannabinoids profoundly suppress cardiac contractility in hypertension and can normalize blood pressure, leading some experts to speculate that the manipulation of the endocannabinoid system “may offer novel therapeutic approaches in a variety of cardiovascular disorders.”

The administration of natural cannabinoids has yielded conflicting cardiovascular effects on humans and laboratory animals.  The vascular response in humans administered cannabis in experimental conditions is typically characterized by a mild increase in heart rate and blood pressure.  However, complete tolerance to these effects develops quickly and potential health risks appear minimal.

In animals, cannabinoid administration in animals is typically associated with vasodilation, transient bradycardia and hypotension, as well as an inhibition of atherosclerosis (hardening of the arteries) progression.  The administration of synthetic cannabinoids have also been shown to lower blood pressure in animals and have not been associated with cardiotoxicity in humans.

At this time, research assessing the clinical use of cannabinoids for hypertension is in its infancy though further investigation appears warranted.
Furthermore, the (Phase III) hypotensive properties of anandamide and some other CB1 receptor agonists have led to the proposal that the cannabinoid system could offer therapeutic targets for hypertension, particularly since Kunos and co-workers have demonstrated that cannabinoid-induced falls in blood pressure are enhanced in chronically hypertensive rats, including spontaneous hypertensive rats (SHR). (Lake et al., 1997a; Batkai et al.,  In summary, we have shown that anandamide induced a dose-dependent, delayed hypotension, which was associated with peripheral vasodilatation in conscious, acutely hypertensive rats.  The synthetic cannabinoid, WIN55212-2 also caused depressor and enhanced vasodilator effects in acute hypertension.  While these data extend previous observations relating to the ability of cannabinoids to lower blood pressure in hypertension, the results clearly show that the mechanisms of action involved depend on the cannabinoids, and it remains unclear whether modulators of the endocannabinoid system are sufficient to normalize cardiovascular variables in hypertension.

Smoking is certainly deleterious to the cardiovascular system.  Nevertheless, chronic smoking of cannabis has been associated with lower blood pressure and with symptomatic hypotension.

Lowering Of Blood Pressure Achieved Through Use Of Hashish-Like Drug  (cannabigerol)

The cannabinoid CB1 and CB2 receptors and endocannabinoid degrading enzymes are present in cardio-vascular tissues. Activation of cardiovascular CB1 receptors leads to hypotension and decreased cardiac contractility. However, the role of myocardial CB2 receptors is still elusive. The ECS plays a limited role in cardiovascular regulation under normal physiological conditions. In various forms of shock and heart failure, the ECS may become overactivated and contribute to depressed cardiovascular function, which can be prevented or attenuated by CB1 antagonists.

Cannabis is known to reduce hypertension to normal levels with regular use and to maintain normal levels with continued use in some cases. Because of repeated threats by the federal government, only a few physicians have elected to recommend medical marijuana in cases of severe high blood pressure.
Recent research indicates that the body's internal cannabinoid system plays an important role in regulating blood pressure, but a full understanding of the exact mechanisms awaits further research.  Animal studies have demonstrated that annadamide and other endocannabinoids suppress hypertension.
In summary, we have shown that anandamide induced a dose-dependent, delayed hypotension, which was associated with peripheral vasodilatation in conscious, acutely hypertensive rats.  The synthetic cannabinoid, WIN55212-2 also caused depressor and enhanced vasodilator effects in acute hypertension. While these data extend previous observations relating to the ability of cannabinoids to lower blood pressure in hypertension, the results clearly show that the mechanisms of action involved depend on the cannabinoids, and it remains unclear whether modulators of the endocannabinoid system are sufficient to normalize cardiovascular variables in hypertension.

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